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Sleeping well as you travel on will guarantee that you reach your destination rested and refreshed.You have three comfort categories: Regular or Deluxe sleeper compartments, the Couchette car when travelling in large groups and the Reclining seats, a seated car with compartments with 6 seats or roomy open-saloon cars with reclining seats. Single, Double or Three-Bed compartments: These options offers room for up to three people travelling together in one compartment.
Breastfeeding is classified by the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) as probably protective against breast cancer. Breast cancer risk increases by 3% for each year older a woman is when she first gives birth, a meta-analysis showed. The association may be limited to ER/PR-positive tumours.[2-4] ER/PR-positive breast cancer risk is 15% higher in women who first gave birth at an older age, compared with those who did so at a younger age, a meta-analysis showed. HER2-positive and triple-negative breast cancers are not associated with age at first birth. Conversely among BRCA1 mutation carriers, breast cancer risk may be lower in those who are older at first birth, meta-analyses have shown;[5,6] among BRCA2 carriers, breast cancer risk is not associated with age at first birth.[5,6] Breast cancer risk increases by 5% for each year younger at menarche (first menstrual period), a meta-analysis has shown. The association is stronger for oestrogen receptor (ER)-positive and progesterone receptor (PR)-positive tumours than for ER- and PR-negative tumours. Breast cancer risk may be higher in women whose breast development started at a younger age, a cohort study indicates. Among BRCA1 mutation carriers too, breast cancer risk may be higher in those who are younger at menarche, a meta-analysis showed; among BRCA2 carriers, breast cancer risk is not associated with age at menarche.[4,5] Breast cancer risk increases by around 3% for each year older at menopause, a meta-analysis has shown. Post-menopausal women (natural menopause or induced by surgery) have a lower risk of breast cancer than pre-menopausal women of the same age and childbearing pattern, a meta-analysis showed. Breast cancer risk is not associated with tubal sterilisation, a meta-analysis showed. Breast cancer risk is 24-41% lower in women who have hysterectomy and oophorectomy before menopause, compared with women who do not have these surgeries, a pooled analysis and case-control study showed.[2,3] Hysterectomy and oophorectomy after menopause may be associated with increased breast cancer risk if oestrogen therapy is used after the surgery, a pooled analysis showed. Current or recent use of combined oestrogen-progestogen oral contraceptives (OCs) is classified by the International Agency for Research on Cancer (IARC) as a cause of breast cancer. An estimated 1% of female breast cancers in the UK are linked to OCs; because breast cancer risk is generally low in the OC-using population (typically younger women), OC-related risk contributes a relatively small number of additional cases. OCs contain synthetic sex hormones, which may explain the link between OC use and breast cancer risk.Celles-ci lui donnent un étrange pouvoir, celui de faire avouer leurs plus noirs secrets aux gens qu’il croise.Ignatius se lance alors à la recherche du véritable meurtrier…This stunning retreat has been in my personal vision for over a decade and it’s even more beautiful, remote and emotive than I ever imagined.This unique retreat is located deep in the heart of sun-drenched Portugal.