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Sleeping well as you travel on will guarantee that you reach your destination rested and refreshed.You have three comfort categories: Regular or Deluxe sleeper compartments, the Couchette car when travelling in large groups and the Reclining seats, a seated car with compartments with 6 seats or roomy open-saloon cars with reclining seats. Single, Double or Three-Bed compartments: These options offers room for up to three people travelling together in one compartment.

Breastfeeding is classified by the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) as probably protective against breast cancer.[1] Breast cancer risk increases by 3% for each year older a woman is when she first gives birth, a meta-analysis showed.[1] The association may be limited to ER/PR-positive tumours.[2-4] ER/PR-positive breast cancer risk is 15% higher in women who first gave birth at an older age, compared with those who did so at a younger age, a meta-analysis showed.[4] HER2-positive and triple-negative breast cancers are not associated with age at first birth.[4] Conversely among BRCA1 mutation carriers, breast cancer risk may be lower in those who are older at first birth, meta-analyses have shown;[5,6] among BRCA2 carriers, breast cancer risk is not associated with age at first birth.[5,6] Breast cancer risk increases by 5% for each year younger at menarche (first menstrual period), a meta-analysis has shown.[1] The association is stronger for oestrogen receptor (ER)-positive and progesterone receptor (PR)-positive tumours than for ER- and PR-negative tumours.[2] Breast cancer risk may be higher in women whose breast development started at a younger age, a cohort study indicates.[3] Among BRCA1 mutation carriers too, breast cancer risk may be higher in those who are younger at menarche, a meta-analysis showed; among BRCA2 carriers, breast cancer risk is not associated with age at menarche.[4,5] Breast cancer risk increases by around 3% for each year older at menopause, a meta-analysis has shown.[1] Post-menopausal women (natural menopause or induced by surgery) have a lower risk of breast cancer than pre-menopausal women of the same age and childbearing pattern, a meta-analysis showed.[1] Breast cancer risk is not associated with tubal sterilisation, a meta-analysis showed.[1] Breast cancer risk is 24-41% lower in women who have hysterectomy and oophorectomy before menopause, compared with women who do not have these surgeries, a pooled analysis and case-control study showed.[2,3] Hysterectomy and oophorectomy after menopause may be associated with increased breast cancer risk if oestrogen therapy is used after the surgery, a pooled analysis showed.[2] Current or recent use of combined oestrogen-progestogen oral contraceptives (OCs) is classified by the International Agency for Research on Cancer (IARC) as a cause of breast cancer.[1] An estimated 1% of female breast cancers in the UK are linked to OCs; because breast cancer risk is generally low in the OC-using population (typically younger women), OC-related risk contributes a relatively small number of additional cases.[2] OCs contain synthetic sex hormones, which may explain the link between OC use and breast cancer risk.Celles-ci lui donnent un étrange pouvoir, celui de faire avouer leurs plus noirs secrets aux gens qu’il croise.Ignatius se lance alors à la recherche du véritable meurtrier…This stunning retreat has been in my personal vision for over a decade and it’s even more beautiful, remote and emotive than I ever imagined.This unique retreat is located deep in the heart of sun-drenched Portugal.

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